Mix ricotta, mozzarella, parmesan, egg, garlic powder, onion powder, salt, and pepper in a bowl.
Fold in chopped shrimp and crab, then mix in parsley.
Melt butter in a saucepan, add garlic, and sauté for 1 minute.
Pour in heavy cream and simmer gently.
Stir in parmesan and Italian seasoning; cook until thickened.
Adjust seasoning with salt and pepper.
Lay cooked lasagna noodles flat and spread 2–3 tbsp filling on each.
Roll each noodle tightly.
Pour a thin layer of Alfredo sauce into a baking dish.
Place roll-ups seam-side down in the dish.
Cover with remaining Alfredo sauce.
Sprinkle mozzarella on top.
Bake covered at 375°F (190°C) for 20 minutes.
Remove foil and bake 10 more minutes until bubbling.
Let rest 5–10 minutes before serving.